陈文生，男，副主任，副教授，副主任医师，硕士生导师。医学博士，耶鲁大学博士后，研究所副所长。从医20余年，具有丰富的临床经验。从事肝胆汁淤积、肝硬化腹水和原发性肝癌发病机制及治疗研究。先后主持四项国....

陈文生，男，副主任，副教授，副主任医师，硕士生导师。医学博士，耶鲁大学博士后，研究所副所长。从医20余年，具有丰富的临床经验。从事肝胆汁淤积、肝硬化腹水和原发性肝癌发病机制及治疗研究。先后主持四项国家自然科学基金研究课题。在JBC、AJP和Hepatology发表论文10篇。任中华消化病学会肝胆疾病协作组成员。主要发表论文如下：1.NuclearreceptorsRXRα:RARαarerepressorsforhumanMRP3expression。AmJPhysiolGastrointestLiverPhysiol.2007;292:G1221-G12272.Tumornecrosisfactora–dependentup-regulationofLrh-1andMrp3(Abcc3)reducesliverinjuryinobstructivecholestasis.JBiolChem2003;278(38):36688-983.Acomparisonofgeneexpressioninmouseliverandkidneyinobstructivecholestasisutilizinghigh-densityoligonucleotidemicroarraytechnology.WorldJGastroenterol2006;12(16):2536-2548.4.Effectsofinsulin-likegrowthfactors-IRand-IIRantisensegenetransfectiononthebiologicalbehaviorsofSMMC-7721humanhepatomacells.JGastroenterolHepatol.2003Mar;18(3):296-3015.Multidrugresistance-associatedprotein4isup-regulatedinliverbutdown-regulatedinkidneyinobstructivecholestasisintherat.JHepatol2004;40:585-591.6.ReleaseoftranscriptionalrepressionfromRXRalphaandRARalpharesultsinup-regulationofMRP3inobstructivecholestasis.Hepatology2004;40(4),suppl.170A7.Plasmamembranelocalizationofhumanorganicanion-transportingpolypeptideC(hOATP-C).Hepatology38(4),suppl.1487A,2004.8.Thecholesterol-7ahydroxylasepromoterfactor(CPF)up-regulatesthehumanmultidrugresistance-associatedprotein3(MRP3)andisinducedbybilesaltsinHepG2cells.Hepatology2003;38(4)Suppl.1:195A9.MRP3/Mrp3(ABCC3/Abcc3)isup-regulatedbyTNFviacholesterol7hydroxylasepromoterfactor(CPF)andishepatoprotectiveinobstructivecholestasis.Hepatology2003;38(4)Suppl.1:168A10.Nuclearhormoneregulationofthehumanmultidrugresistanceprotein(MRP3)geneinhumanhepatomacelllines。Hepatology2002;36(4)Suppl.2:343A.